Figure 5
Regulation and role of Bcl-xL, Bim, and Noxa in PC differentiation. (A) qPCR analysis of mRNA levels in sorted p18+/+ and p18−/− populations on day 7 after NP-CGG immunization. (B) Percentage of live aBCs, iPCs, and PCs in individual Bim+/+ and Bim+/− mice (P < .05, n = 4). (C) Percentage of live and TO-PRO-3+ aBCs, iPCs, and PCs in individual Bcl-xL+/+ and Bcl-xLTg/Tg mice (P < .001, n = 4); and (D) Total live aBCs, iPCs, and PCs in each spleen and percentage of live and TO-PRO-3+ cells in Noxa+/+ and Noxa−/− mice (P < .05, n = 4).
