The more N-terminal hirudin-like sequence of FVa2, Glu⁶⁶⁶-Glu⁶⁷², binds across thrombin exosite I. Close-up around the thrombin exosite I region in the FPR–α-thrombin·FVa2 complex. For simplicity, only residues of thrombin 70-80 loop, a few side chains of the neighboring 37 loop, and a water molecule trapped at the thrombin-FVa2 interface are included in the image. Thrombin residues are color-coded blue-purple (carbon), dark blue (nitrogen) and red (oxygen), and are overlaid with a transparent surface; FV atoms are green (carbon), dark blue (nitrogen) or red (oxygen). Electrostatic interactions are indicated with dashed yellow lines.