OPN mRNA expression and survival. High OPN expression on the mRNA level is associated with significantly (P = .001) shorter OS (A) and EFS (P = .0002; B). In the group of AML patients who reached remission, increased OPN expression still showed significantly shorter EFS (P = .006; C) and this was also true in intermediate-risk patients (as defined by cytogenetics; P = .045; D).