Particular monocyte subpopulations after anti–M-CSF mAb infusions. Changes in the absolute number of circulating classical (A), intermediate (B), and nonclassical (C) monocytes after infusions of anti–M-CSF mAbs (dashed line) or placebo (solid line). (D) The dot plots show changes of the monocyte subpopulations during the first 4 weeks after initial anti–M-CSF mAb infusion in female patient; lack of nonclassical monocytes on day 7, very low number on day 14, and growing number of intermediate monocytes on days 7-28.