Gene expression microarrays in primary B-lymphoblastic leukemia patient samples and cell lines reveal reversal of relapse-specific signature. Heat map showing the effect of vorinostat in reversing the relapse-specific gene expression profile. Rows represent individual genes (154 probes); relative overexpression is shown in red and underexpression in green. The first 3 columns are primary patient samples (1, 2, and 3), followed by the Reh, RS4:11, and MV4:11 cell lines, respectively, before treatment with vorinostat; the next 6 columns correspond to each sample after treatment.