Classification of clinical PNH*
PMNs indicates polymorphonuclear cells.
Based on the recommendations of the International PNH Interest Group.13
†Based on macroscopic hemoglobinuria, serum LDH concentration, and reticulocyte count.
‡Karyotypic abnormalities are uncommon.
§Aplastic anemia or low-risk MDS.
¶Analysis of PMNs is more informative than analysis of RBCs due to selective destruction GPI-AP–deficient RBCs.
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