Evolution rate to clonal disease including PNH and MDS
*Patients who were treated only with ALG.
†Probability of developing all hematological complications (PNH, MDS/AML).
‡Frequency based on 209 patients who are long-term survivors; MDS, n = 11 (5 of which subsequently evolved to acute leukemia); acute leukemia, n = 1.
§Patients treated with IST; MDS, n = 19; AML, n = 15.
¶Two of these patients had concurrent MDS.
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