Figure 2.
The genes encoding factor H and the factor H–related proteins lie in a centromeric segment of the regulators of complement activation cluster at 1q32. Genomic duplications including the different exons of the 6 genes (originally determined by Male et al12 ) are shown in panels A-D by color coding. Exons are indicated as vertical lines. The shaded box shows how a deletion occurring as a result of nonallelic homologous recombination results in a hybrid gene consisting of the first 21 exons of CFH (encoding SCRs 1-18 of the hybrid gene) and the last 2 exons of CFHR1 (encoding SCRs 19 and 20 of the hybrid gene). (Adapted from Venables et al.)
