Graphical view of selected gene products based on Ingenuity Pathways Analysis. A cell is shown as an oval (the inner oval represents the nuclear membrane, the 2 outer ovals represent the plasma membrane) depicted at 4 different time points chosen for analysis (60 minutes, 90 minutes, 210 minutes, 390 minutes). Gene products in gray are located according to their respective known function within in the cell graph. Interaction edges between gene products are derived from Ingenuity Systems learning results. Expressed genes at each time point are represented successively in yellow (expressed in every healthy and malignant B cell), orange (differentially expressed between CLL and healthy B cells), and red (differentially expressed between aggressive CLL and indolent CLL). The expression of 3 main different functional group of genes (early transcriptional factors, MYC and NFκB) is represented in the graph across time. The malignant and aggressive malignant specific genes are integrated in these common functional groups of expressed genes and interfere mainly with the life and death balance at multiple levels.