Modulation of PP2A overrides SET-mediated regulation of granzyme B expression in human NK cells. pSUPER-infected and pSUPER.retro-shSET-infected NK-92 cells were treated for 15 hours with vehicle (DMSO) or the PP2A inhibitor okadaic acid (10nM). Cell pellets were collected and assayed for granzyme B protein by Western blot (A) and granzyme B mRNA by real-time RT-PCR (B; n = 4). *P < .02. Each experiment is representative of at least 3 performed with similar results.