Effect of SET modulation or pharmacologic induction of PP2A activity on ADCC. pSUPER-infected and pSUPER.retro-shSET-infected NK-92 cells were infected with PINCO-CD16α chain virus and sorted for coexpression of GFP and CD16. After sorting, CD16 membrane expression was confirmed by FACS analysis (A, left), and down-modulation of SET was confirmed by immunoblotting (A, right). (B) ADCC of pSUPER-infected and pSUPER.retro-shSET–infected NK-92 cells expressing CD16 (n = 4, *P < .02) and (C) ADCC of primary CD56⁺ NK cells incubated in DMSO vehicle control or 1,9-dideoxy-forskolin (n = 5, **P < .01). Effector cells were assayed against P815 antibody-coated target cells in a 3-hour ⁵¹Cr release assay. Each experiment is representative of at least 3 performed with similar results.