Patients with myeloma have lowered SOD2 expression compared with that of healthy donors. (A) A box plot of SOD2 expression in samples from patients with myeloma and healthy donors. The SOD2 data (Affymetrix microarray element X65965; Santa Clara, CA) is from the database available at http://www.myeloma.uams.edu/lambertlab/software.asp (datasets “Affymetrix HuGeneFL*.txt for 74 newly diagnosed multiple myelomas” and “Affymetrix HuGeneFL*.txt for 31 normal bone marrow–derived plasma cells”).²⁰  (B) The individual expression levels for each sample are plotted, and lines indicate the median and lowest SOD2 expression level of the healthy donor samples. The difference in SOD2 expression in statistically significant (P < .001).