Abnormal morphology of interphase and mitotic AEtr cells. (A-C) Giemsa staining of interphase vector control nuclei. (D) Chromosome spread of a prometaphase vector control cell. (E) Giemsa staining of interphase AEtr nuclei. Arrows indicate chromosome bridges. (F) Polyploid AEtr interphase cells (indicated by arrows). (G) Lagging chromosomes (indicated by arrow) during anaphase of an AEtr cell. (H) Premature sister chromatid separation in an AEtr prometaphase cell. Images were captured with a Leica DMLB microscope with a 100×/_ oil objective and a Spot 2 digital camera (Diagnostic Instruments, Sterling Heights, MI) using Spot v.4.64 software. Images were processed with Adobe Photoshop 5.5 (Adobe Systems, San Jose, CA).