Solulin increases the MCF and AUEC in human hemophilic blood with minimal effect on CLT. (A) The maximum clot firmness (MCF) increased from 25.3 ± 4.5 mm to 43.2 ± 6.6 mm in the presence of 1.4-17.9nM Solulin (P < .01). At higher concentrations, the MCF decreased from peak values. (B) In severe hemophilia A, the area under the elasticity curve (AUEC) is increased by ∼ 4-fold in the presence of Solulin due in part to an increase in MCF but also to an increased clot lysis time (CLT). (C) Solulin marginally increases the CLT in hemophilia A blood. At the lowest concentrations of Solulin (< 7.1nM), the CLT increased marginally from 11.2 ± 1.9 to 12.9 ± 3.7 minutes. The increase in CLT with Solulin was not statistically significant even at 35.7nM (P = .07). This is Figure 2 from the article by Foley et al that begins on page 3622 of this issue.