Schematic summarizing the overall study design. A stepwise approach was followed to select 6 genes for an association study in cases of MI and controls. The results of the association study prompted a study to determine the effect of the silencing of 2 genes on thrombus formation in D rerio. The protein encoded by the gene with the strongest effect on thrombus formation was selected for proteomics analysis in human platelets. PFC, Platelet Function Cohort; CAD, coronary artery disease; WTCCC, Wellcome Trust Case Control Consortium; GWAS, genome-wide association study; SNP, single-nucleotide polymorphism. Inclusion of the 6th gene (GTF2A2) was based on association of expression with all 4 measures of the platelet response and association.