Box plots showing the effect of sequence variation in the COMMD7, LRRFIP1, and PFKL genes on the platelet response. Data are shown for the SNPs that showed the lowest P value in the PFC and the lowest P value in the replication MI/CAD cohort. The association between sequence variation and the platelet response is shown as the mean and interquartile range. Platelet activation was measured by flow cytometry, and data are shown as the standardized residuals of logit transformed data, after adjustment for confounding variables, as described by Jones et al.1 PA, P-selectin expression in response to ADP; FA, fibrinogen binding in response to ADP. Numbers (n) below graphs indicate the numbers of subjects homozygous for the major allele (1), heterozygous (2), or homozygous for the minor allele (3).
