Kaplan-Meier estimates of TFS and cumulative probability of transformation to RS according to NOTCH1 mutation status. TFS according to NOTCH1 mutation status (A) and cumulative probability of transformation to RS (B) in the CLL training series (n = 309). NOTCH1 germ line cases (NOTCH1 GL) are represented by the blue line. NOTCH1 mutated cases (NOTCH1 M) are represented by the red line.