Networks most highly represented by transcripts differentially associated with HuR after IR treatment. (A) Genes related to the mitogen-activated protein kinase signaling pathway, showing altered association with HuR after IR were visualized on KEGG pathway maps. (B) The top ranked network of genes differentially associated with HuR after IR in ATM wild-type but not in ATM null lymphocytes as defined by IPA “DNA Replication, Recombination, and Repair, Nucleic Acid Metabolism, Small Molecule Biochemistry.” Red represents up-regulated genes; and green, down-regulated genes. Solid lines indicate direct interaction between genes; and dashed lines, indirect interaction between genes.