Figure 4
![Figure 4. FdUMP[10] causes S-phase arrest regardless of p53 status. (A) EdU (5-ethynyl-2′-deoxyuridine) incorporation assays. MLL-ENL–driven murine AML cells were incubated with the indicated drug for 8 hours and subjected to an EdU incorporation assay. S-phase cells were gated as shown. Percentages shown are for cells in S phase. (B) EdU incorporation assay as in panel A. Cells were infected with either a p53-targeting shRNA or a control vector and exposed to the indicated drug for 8 hours.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/119/15/10.1182_blood-2011-06-362442/5/zh89991288960004.jpeg?Expires=1735503485&Signature=NC5Tw6k~38eZeKbtvpfikgsRMCCOZXOF8nKJ9huc-LjqgZiBDYSge8hazBZh~5BjUQraoE1pmHGAAjypv-DyKXDyzrrMd7dt9FXN~kN8v7aa1G4OJEsX4o8-MKJCmhMieoBcrevFR74jPraOoJEvZyVWb9nQC6LwwRjkq0CrIyOjq6TlUZA1lBLYSQ3~thjeaLPYcQF-S3cYIdJ-GO1IOVkE19cZVngPDRUtmpi0ZXbQ2q5IwJom1-1WnNmdkqqIzaTlGM0nhvNOoPDcrSLb8ykE30KJV5uESq7aKaTYiGvmlxzj0-eBfBAuoKZomrY7DX7sbKko72nLRk9CqQZgJw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
FdUMP[10] causes S-phase arrest regardless of p53 status. (A) EdU (5-ethynyl-2′-deoxyuridine) incorporation assays. MLL-ENL–driven murine AML cells were incubated with the indicated drug for 8 hours and subjected to an EdU incorporation assay. S-phase cells were gated as shown. Percentages shown are for cells in S phase. (B) EdU incorporation assay as in panel A. Cells were infected with either a p53-targeting shRNA or a control vector and exposed to the indicated drug for 8 hours.
