Figure 6
![Figure 6. FdUMP[10] confers a survival benefit equivalent to the combination of Ara-C and Dox. (A) Schema of treatment trial. C57/Bl6 mice were sublethally irradiated to 4.5 Gy and injected with an MLL-ENL and Flt3 ITD syngeneic leukemia. Once engraftment was established by bioluminescence imaging, mice were treated with either saline (S), FdUMP[10] at 300 mg/kg (Fd), 5-FU at 121 mg/kg or Ara-C at 125 mg/kg plus Dox at 3.75 mg/kg (AD) on days 1, 3, 5, and 7. (B) Bioluminescent image of mice on day 6 after treatment. (C) Kaplan-Meier curves for animals treated with Fd, 5-FU, or AD as in panel B.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/119/15/10.1182_blood-2011-06-362442/5/zh89991288960006.jpeg?Expires=1735824304&Signature=45PcGkBaRS3OnxeD2HqZIUJwIIbLu7m3aFk-wEvH69XKAMOftaSUswgnSUtMM6QfmHwu~YwOK9bSXgWsn4qBedtu5wUXQg8iNSl-QJfJ8DFV4RKvS85Xd1FGC~CbTgrp9JVqaYcYuqPq5bPayxfuoZ1ARxX3q7tVVT~xS7Yq-Rlq1jAJwtGbTJA2GTG71T17vzYWCl8VF89lCxiItetZEhUgZmo7nT0P30rzjXIsmHLQ143d~jd~76tPn53vM7HmeHLJloC3gUS2QPsNErIRajYbG5mYkNhEGBgYKVvUG7WOYvLi4UkobWSJ~9h6J2UsHLDMXQs~wdlgFq4s3ksLTQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
FdUMP[10] confers a survival benefit equivalent to the combination of Ara-C and Dox. (A) Schema of treatment trial. C57/Bl6 mice were sublethally irradiated to 4.5 Gy and injected with an MLL-ENL and Flt3 ITD syngeneic leukemia. Once engraftment was established by bioluminescence imaging, mice were treated with either saline (S), FdUMP[10] at 300 mg/kg (Fd), 5-FU at 121 mg/kg or Ara-C at 125 mg/kg plus Dox at 3.75 mg/kg (AD) on days 1, 3, 5, and 7. (B) Bioluminescent image of mice on day 6 after treatment. (C) Kaplan-Meier curves for animals treated with Fd, 5-FU, or AD as in panel B.
