Histopathologic features of HIV MCD. (A) Lymph node shows a small follicle with relatively atrophic germinal center and mildly expanded mantle zone. The tissue outside the follicle (interfollicular area) is rich in vessels and plasma cells (hematoxylin and eosin; original magnification ×40). (B) Higher magnification of the follicle, including the mantle zone (hematoxylin and eosin; original magnification ×100). (C) Higher magnification of the interfollicular area (hematoxylin and eosin; original magnification ×100). (D) Within the mantle zone, there are several large cells with nucleoli, the so-called “plasmablasts” (hematoxylin and eosin; original magnification ×600).