Immunocytochemical features of HIV MCD plasmablasts. (A) On immunohistochemistry, the large lymphoid cells with nucleoli, the so-called “plasmablasts,” harbor HHV8 virus as demonstrated by the presence of HHV8–latent nuclear antigen-1. The cells express IgM (B) and lambda light chain (D) and are negative for kappa light chain (C). All original magnifications are ×600.