A greatly simplified overview of JAK2^V617F and BCR-ABL (yellow circles) signaling in MPN. Filled lines indicate known biochemical interactions and dotted lines indicate possible interactions. Protein phosphorylation is indicated by a circled red “P.” Other proteins are shown as open circles. PI3K^cat designates the catalytic subunits of PI3K proteins and GNEFs are guanine nucleotide exchange factors for Ras.