Pioglitazone enhances efferocytosis and reduces accumulation of apoptotic neutrophils in CGD mice. Mice were treated as described in Figure 4. Efferocytosis by peritoneal macrophages (A) and accumulation of apoptotic neutrophils (identified by nuclear morphology) (B) were determined microscopically. In vivo uptake of carboxylated beads by macrophages was determined by flow cytometry (C) as in Figure 3. Data represent mean ± SE; N = 8 mice per time point; #P ≤ .01 compared with vehicle-treated CGD mice at the respective time points; *P ≤ .01 compared with WT mice treated with vehicle, at the respective time points. αP < .02 between baseline [B] and 6-hour after zymosan for the corresponding genotype and treatment condition, respectively.