Clustering of AML patient samples according to methylation profiling with HELP. Distribution of DNMT3A^mutant and DNMT3A^wild-type AMLs. Pearson correlation view based on methylation profiling of 334 AML cases (see previous figure from Figueroa et al²⁵ ). The presence (red) or absence (green) of NPM1 mutation, FLT3-ITD, or DNMT3A mutation is indicated for the individual AML cases adjacent to the correlation matrix. The distinct FAB types are indicated in different colors.