American Society of Hematology

Figure 3

$Figure 3. Sustained expression of miR-cluster 99b/let-7e/125a or miR-125a alone disturbs hematopoiesis. (A) WBC, RBC, and platelet counts at 10 weeks after transplantation (n = 9-18 mice/group). P values (*.01 < P < .05; ***P < .001) are displayed (Mann-Whitney test). (B) Chimerism levels were assessed at 10 weeks after transplantation by analyzing the percentage of EGFP+ cells in the donor fraction (n = 9-18 mice/group). The arrows indicate the increase in chimerism levels over the first 10 weeks after transplantation. (C) Cell-type distribution in the blood as assessed by FACS (n = 9-18 mice/group). Shown is the mean ± SEM (D) Survival of mice (n = 9-18 mice/group). The gray box indicates the time point analyzed in the other panels. WBC indicates white blood cells; RBC, red blood cells; PLT, platelets; GM, granulocytes/macrophages; B, B lymphocytes; T, T lymphocytes; and O, other cell types.$

Sustained expression of miR-cluster 99b/let-7e/125a or miR-125a alone disturbs hematopoiesis. (A) WBC, RBC, and platelet counts at 10 weeks after transplantation (n = 9-18 mice/group). P values (*.01 < P < .05; ***P < .001) are displayed (Mann-Whitney test). (B) Chimerism levels were assessed at 10 weeks after transplantation by analyzing the percentage of EGFP⁺ cells in the donor fraction (n = 9-18 mice/group). The arrows indicate the increase in chimerism levels over the first 10 weeks after transplantation. (C) Cell-type distribution in the blood as assessed by FACS (n = 9-18 mice/group). Shown is the mean ± SEM (D) Survival of mice (n = 9-18 mice/group). The gray box indicates the time point analyzed in the other panels. WBC indicates white blood cells; RBC, red blood cells; PLT, platelets; GM, granulocytes/macrophages; B, B lymphocytes; T, T lymphocytes; and O, other cell types.

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