Variables independently predictive of outcome in full cohort. After stepwise multivariate analysis, 4 variables were independently correlated with outcome among the cases tested: (A) NCI risk group, (B) MRD, (C) high CRLF2 expression, and (D) dIKZF1 status. Their correlations with outcome are depicted in Kaplan-Meier survival plots, stratified by NCI risk group. Black lines indicate NCI SR; and red lines, NCI HR. The hazard ratios and log-rank P values were calculated separately for the 2 NCI risk groups and are shown in black (NCI SR) and red (NCI HR) at the bottom of each plot.