ZA rescues trabecular, but not cortical, bone loss. (A) Schematic for the treatment schedule of leukemic and normal mice with ZA. Leukemia was initiated on day 0 after 2 weeks of ZA treatment. Arrows indicate injection of ZA. (B) Serum CTX levels in normal mice after 2 weeks of treatment with ZA. (C) Serum CTX levels in normal and leukemic mice after the ZA treatment schedule. (D) Trabecular bone volume/total volume. (E) Cortical bone volume/total volume. *P < .05 (F) Trabecular number. (G) Trabecular spacing in normal or leukemic mice as quantified by micro-CT analysis after treatment with ZA. **P ≤ .01. ***P ≤ .001. (D-G) n = 4 mice per treatment group.