mAb 2021 duration of action study. (Left axis, line) Plasma mAb 2021 in rabbits dosed with 20 mg/kg intravenously and (right axis, bars) blood loss after cuticle bleeding induced at 4, 7, and 10 days after administration of mAb 2021, expressed as percentage of blood loss in control rabbits dosed with isotype control Ab (n = 8). *P < .05 compared with the corresponding control group.