Treatment of an ongoing bleed. Blood loss in rabbits with Ab-induced hemophilia (FVIII Ab at −45 minutes) when treated with isotype control Ab, 2 mg/kg mAb 2021, or 9 mg/kg rFVIIa 5 minutes after induction of cuticle bleeding. The bleed was observed for 1 hour. P values are compared with the hemophilia control group.