Platelet P-selectin plays a minor part in VWF-mediated PMN recruitment. Mice were lethally irradiated and reconstituted either with wt or P-selectin^−/− donor bone marrow. Animals were treated with control antibodies (Co-IgG) or anti-VWF antibodies before peritonitis was induced with thioglycollate. Normalized results of 3 independent assays are shown (number of mice per group ≥ 11). Numbers indicate the percentage of reduction in comparison to wt transplanted, Co-IgG treated mice. Error bars show SEM. ***P ≤ .001; **P ≤ .01.