American Society of Hematology

Figure 1

$Figure 1. Viro-immunologic features in éLTNP and naive patients. (A) éLTNP patients had fewer peripheral activated T lymphocytes (triple negative cells) in comparison with those of naive patients, either among CD4+ or CD8+ T lymphocytes. Pie charts (top) and bars (referred to median values) among dots (bottom) show the qualitative composition of activated CD4+ or CD8+ T cells in éLTNP patients (blue and red dots, respectively) and in naive patients (green and orange dots, respectively). Each pie graph represents the mean proportion of the different populations identified by anti-CD38 (b indicates bright, ie, cells with high amounts of CD38 on the cell surface; d, dim, cells with low amounts of CD38) and anti–HLA-DR mAbs as indicated in the legend under the histograms. Arcs designed outside the pies represent the fraction of total cells expressing a particular marker, irrespective of the positive or negative expression of other markers (blue, CD38 bright; red, CD38 dim; green, HLA-DR). (B) No relevant differences were observed in analysis of differentiation markers (ie, virgin or memory T cells whether or not expressing CD127). Pie charts (top) and bars (referred to median values) among dots (bottom) show the differentiation of CD4+ or CD8+ T cells in éLTNP patients (blue and red dots, respectively) and in naive patients (green and orange dots, respectively). Each pie graph represents the mean proportion of the different populations identified by anti-CCR7, anti-CD45RA, and anti-CD127 mAbs as indicated in the legend under the histogram. Arcs designed outside the pies represent the fraction of total cells expressing a particular marker, irrespective of the positive or negative expression of other markers (blue, CCR7; red, CD45RA; green, CD127). (C) éLTNP patients had fewer regulatory T cells expressing HLA-DR, higher numbers of sjTREC+ cells, and less intracellular HIV-1 DNA within CD4+ T lymphocytes than naive patients. Boxes limit the first and third quartile, the line in the box represents the median value; whiskers indicate minimum and maximum.$

Viro-immunologic features in éLTNP and naive patients. (A) éLTNP patients had fewer peripheral activated T lymphocytes (triple negative cells) in comparison with those of naive patients, either among CD4⁺ or CD8⁺ T lymphocytes. Pie charts (top) and bars (referred to median values) among dots (bottom) show the qualitative composition of activated CD4⁺ or CD8⁺ T cells in éLTNP patients (blue and red dots, respectively) and in naive patients (green and orange dots, respectively). Each pie graph represents the mean proportion of the different populations identified by anti-CD38 (b indicates bright, ie, cells with high amounts of CD38 on the cell surface; d, dim, cells with low amounts of CD38) and anti–HLA-DR mAbs as indicated in the legend under the histograms. Arcs designed outside the pies represent the fraction of total cells expressing a particular marker, irrespective of the positive or negative expression of other markers (blue, CD38 bright; red, CD38 dim; green, HLA-DR). (B) No relevant differences were observed in analysis of differentiation markers (ie, virgin or memory T cells whether or not expressing CD127). Pie charts (top) and bars (referred to median values) among dots (bottom) show the differentiation of CD4⁺ or CD8⁺ T cells in éLTNP patients (blue and red dots, respectively) and in naive patients (green and orange dots, respectively). Each pie graph represents the mean proportion of the different populations identified by anti-CCR7, anti-CD45RA, and anti-CD127 mAbs as indicated in the legend under the histogram. Arcs designed outside the pies represent the fraction of total cells expressing a particular marker, irrespective of the positive or negative expression of other markers (blue, CCR7; red, CD45RA; green, CD127). (C) éLTNP patients had fewer regulatory T cells expressing HLA-DR, higher numbers of sjTREC⁺ cells, and less intracellular HIV-1 DNA within CD4⁺ T lymphocytes than naive patients. Boxes limit the first and third quartile, the line in the box represents the median value; whiskers indicate minimum and maximum.

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