Effects of anticoagulant treatment on bleeding in a mouse hepatectomy surgical bleeding model. Mice were treated with vehicle (saline), FXI or FII ASO (20 mg/kg twice/week for 3 weeks), or Lovenox (50 mg/kg once/day on 3 consecutive days). Two days after ASO treatment or 2 hours after Lovenox treatment, animals underwent a surgical hepatectomy procedure. Four hours after incision closure, relative bleeding was determined by measuring red blood cell count, hemoglobin levels, and hematocrit values. *P ≤ .05 compared with vehicle group with surgery.