Examples of motifs enriched in Hoxa9-associated enhancers. Enriched motifs, each depicted as a colored rectangular box, are plotted for the central 200 bp of 8 representative Hoxa9-bound enhancers. These Hoxa9 enhancers are highly enriched for HOX, HOX-MEIS-PBX, CREB, MYB, CAUDAL, ETS, MYC, and STAT sites, among others. All motifs shown are significantly enriched in these Hoxa9 enhancers compared with random genome background (Motif Enrichment Analysis; supplemental Data). An enrichment statistic is computed with z-test comparing the observed frequencies (in H/M peaks) versus the expected frequencies (in random genomic background; P < .001). A complete compendium of motifs is provided in supplemental Data.