Solulin increases the MCF and AUEC in human hemophilic blood with minimal effect on CLT. (A) The MCF increased from 25.3 ± 4.5 mm to 43.2 ± 6.6 mm in the presence of 1.4-17.9nM Solulin (P < .01). At higher concentrations, the MCF decreased from peak values. (B) In severe hemophilia A, the AUEC is increased by approximately 4-fold in the presence of Solulin due in part to an increase in MCF but also to an increased CLT. (C) Solulin marginally increases the CLT in hemophilia A blood. At the lowest concentrations of Solulin (< 7.1nM), the CLT increased marginally from 11.2 ± 1.9 to 12.9 ± 3.7 minutes. The increase in CLT with Solulin was not statistically significant even at 35.7nM (P = .07).