Solulin improves clot stability (AUEC) in human hemophilic blood over a range of fVIII or fIX concentrations (exemplified in single patients). Solulin improvement of clot stability plateaued at concentration ranging from 1.4-7.1nM regardless of fVIII:C (A) or fIX:C (B). Shown is the relative improvement over fVIII:C or fIX:C alone. As the reference AUEC increased after factor infusion, the relative improvement in clot strength by Solulin decreased. The absolute Solulin-dependent increase in AUEC can be calculated by multiplying the relative improvement in AUEC by the AUEC in the absence of Solulin (fVIII or fIX as a percentage, AUEC in units of 10⁴ millimeters per minute; panel A, < 1, 3.67; 102, 11.59; 11.7, 6.31; 1.2, and 2.98; panel B, 1.6, 2.33; 38.2, 7.32; 14.4, and 4.17).