Clot firmness is increased in blood from hemophilic dogs given Solulin at low doses (5 or 10 μg/mL). Thromboelastography shows that the individual response to low-dose Solulin varied among the 3 dogs enrolled (panels A, B, and C show data for doses of 5, 10, and 10 μg/kg, respectively). The most dramatic improvement was observed in dog 2 (B), in which clot strength (amplitude) was increased throughout the 72-hour monitoring period. Dog 4 (D), which was given a high dose of Solulin (500 μg/kg) showed decreased clot strength (amplitude) during the first 24 hours after receiving Solulin. As the concentration of Solulin decreased in dog 4, an improvement in clot strength was observed, suggesting an overdose.