Comparisons of individually estimated in vivo recoveries (IU/dL per IU/kg) and terminal half-lives (t_½; hours) in the 10- to 65-year-old patients, as obtained using 10 (y-axis) and 4 (x-axis) postinfusion sample values. Lines of identity are shown. (A) Recovery, as calculated from dose and the first sample value (R² = 0.982). (B) Model-predicted recovery, as calculated from dose and model-estimated central volume of distribution (V1) in the population pharmacokinetic (PK) model (R² = 0.996). (C) Terminal t_½ as originally estimated by linear regression (R² = 0.985).¹³  (D) Terminal t_½ estimated by the population PK model (R² = 0.997).