Plasma clearance of FVIII and VWF in macLRP1⁺ and macLRP1⁻ mice. MacLRP1⁺ mice (open circles) and macLRP1⁻ mice (closed circles) were given recombinant FVIII (Kogenate; 150 U/kg; A) or pd-VWF (0.25 mg/kg; B). All reagents were given intravenously in the tail vein. Plasma samples were collected at indicated time points and analyzed for FVIII or VWF antigen, respectively. Data represent percentage of residual antigen compared with the amount injected. For each time point, the mean ± SD from 3 to 9 individual mice is shown. For calculation of MRT, data over a 24-hour period were used. The drawn lines were obtained from fitting the data to an equation describing a biexponential decay.