Temporal and spatial regulation of plg during wound healing. (A) Kinetics of the plg levels in the wounds for 18 days after burn wounding in WT (n ≥ 5) and plg^+/− mice (n ≥ 3). (B) Experimental design used to determine the spatial regulation of plg after wounding. (C) Comparison of the plg levels at different distances from the wound 24 hours after wounding in WT mice (n = 5). (D) Comparison of the plg levels at different distances from the wound 24 hours after the IV injection of plg in WT mice (n = 5).