Roquin^san/+ mouse develop asymmetric lymphoadenopathy and splenomegaly. (A) Comparison of enlarged cervical and inguinal lymph nodes with the contralateral normal lymph node in a Roquin^san/+ female mouse. (B) Representative diagram of spleens from 5 Roquin^san/+ and 4 Roquin^+/+ control age-matched mice. *Mice with lymphadenopathy. (C) Spleen weights of Roquin^san/+ mice separated into those with and without lymphadenopathy compared with Roquin^+/+ controls. Mice were 18 to 40 weeks of age. (D) Total serum IgG titres assayed by ELISA. Roquin^san/+ mice with lymph node tumors have a statistically significant increase in serum IgG titres compared with nontumor Roquin^san/+ mice: *P < .05; **P < .01.