VE-cadherin but not N-cadherin inhibits both VEGF and FGF signaling in ECs. (A) Coimmunoprecipitation of VEGFR2 with VE-cadherin but not N-cadherin in VE and N cells. (B-E) Immunoblots and quantification of phospho-p42/44 MAPK and total p42/44 MAPK from N and VE and N+VE cells after 5 minutes of VEGF-A stimulation (80 ng/mL) or 10 minutes of FGF-2 stimulation (20 ng/mL). Cells have been cultured in starving medium for 72 hours before treatment. Columns are means ± SEM, (n = 3; *P < .05, **P < .02).