Enhancer signatures and disease-associated genetic variants. Overlap of H3K4me1 and/or H3K27ac-marked promoter-distal regions (± 3 kb from RefSeq-annotated TSS) with disease-associated sequence variants (SNPs) from the GWAS catalog.¹⁷  Only studies that identified at least 5 SNPs were included in the analysis and shown are all studies with a false discovery rate < 5%. P values for enrichment are presented as a heat map where red indicates significance values. Numbers of total enhancer regions for each cell type are given in brackets above the heat map.