R/LR status is predictive of TTFT in CLL. Kaplan-Meier survival curves for TTFT in our cohort of patients stratified on the basis of Binet staging system, cytogenetic abnormalities, IGHV mutational status, and γδ T-cell proliferative response are shown. P values were calculated by log-rank test. By univariate analysis, advanced Binet stage (B or C; stage B/C, n = 17; stage A, n = 89; A), unfavorable cytogenetic abnormalities (del(11) or del(17) [del(11)/del(17)], n = 20; normal/del(13), n = 81; B), UM IGHV mutational status (UM, n = 34; M, n = 63; C), and LR status (LR, n = 53; R, n = 53; D) correlated with shorter TTFT. By Cox multivariate analysis all the aforementioned parameters were independently associated with shorter TTFT (E).