The combination of IGHV mutational profile and R/LR status identifies groups of CLL patients with different TTFT. Patients were divided into 4 groups on the basis of their IGHV mutational profile and their R/LR status. For each group median TTFT was calculated and compared by Kaplan-Meier analysis. Median TTFT was 29 months for LR-UM (n = 24), 82 months for R-M (n = 40), 93 months for LR-M (n = 23), and was not reached for R-UM patients (n = 10). (A) R-M and LR-UM patients retained a significant difference (P < .001). Among UM CLL patients, the R/LR status was found to further discriminate those who were likely to progress and those who would remain stable, as R patients had a significantly longer TTFT than LR (P = .021). (B) Between-groups comparisons are shown. P values were calculated by log-rank test.