Range of TG responses to rFVIIa doses reveals independent contributions of TF-dependent and phospholipid-dependent mechanisms. FVII-deficient plasma was supplemented with phospholipids (4μM), CTI (50 μg/mL), and rFVIIa (0-1600nM) and activated with 0, 1, and 8pM TF (dotted lines). (A) Comparison of experimental TG (dotted lines) to theoretical simulations (solid lines). (B) Clot time (TF-initiated experiments from panel A) is insensitive to the upper supraphysiological dose range of rFVIIa.