Dynamics of virologic and immunologic parameters of pathogenic SIVagm infection in PTMs. (A) Viral replication. (B) Mucosal CD4⁺ T cells. (C) Levels of immune activation (Ki-67) of CD4⁺ T cells. (D) Levels of immune activation (Ki-67) of CD8⁺ T cells. (E) Dynamics of inflammation as assessed by changes in the levels of IL-6. (F) Prospective assessment of microbial translocation based on testing of the surrogate marker sCD14. Two PTMs (□) died with peritonitis because of surgery complications. In these monkeys, the coagulation markers paralleled the levels of sepsis and inflammation and not viral replication, which was controlled. Index of CD4⁺ T cells is defined by the percentage of depletion from the baseline.