Comparison of prophylactic FIX_WT and FIX_Alb treatment in CRM⁻ mice. SVBA 7 days after infusion of FIX_WT (green) or FIX_Alb (blue) into CRM⁻ mice at 50, 100, 150,and 200 IU/kg. Results for untreated CRM⁻ (purple) and WT (red) mice are also shown. There is no significant difference between the median SVBA values for the FIX agents. Box plot rendition of the results showing the minimum, first quartile, median (waist), third quartile, and maximum values. KO, knockout.