Reduction of blood loss. Blood loss reduction can be achieved by the enhancement of fibrin formation with rFVIIa to increase the formation of FIXa and FXa(a), with desmopressin to stimulate the release of FVIII and VWD(b), or by providing more fibrinogen(c). Another strategy is to decrease the degradation of fibrin by inhibiting the conversion of plasminogen to plasmin with aprotinin, TXA, or EACA(d).