BID indicates twice daily; OD, once daily; P-gp, P-glycoprotein; VKORC1, C1 subunit of the vitamin K epoxide reductase enzyme; 3A4, cytochrome P₄₅₀ 3A4 enzyme.

*Bioavailability of rivaroxaban decreases as the dose is increased because of poor drug solubility; with OD doses of 20 and 10 mg, the bioavailabilities are 60% and 80%, respectively.